Scientific References Check out the scientific literature that supports our molecular targets and our synthetic lethal approach. May 2017 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients Zehir A, Benayed R, Shah RH, et al. Nature September 2016 Synthetic lethality in lung cancer and translation to clinical therapies Leung AW, de Silva T, Bally MB, Lockwood WW Molecular Cancer November 2015 High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities Hart T, Chandrashekhar M, Aregger M, et al. Cell August 2005 The concept of synthetic lethality in the context of anticancer therapy Kaelin WG Jr. Nature February 2004 Global mapping of the yeast genetic interaction network Tong AH, Lesage G, Bader GD, et al. Science 12345 We have a number of synthetic lethal therapies in development. View Pipeline
